Abstract
Hippocampal neurons containing somatostatin have been shown to be vulnerable in some experimental models of epilepsy. In this report, we describe our recent findings about the seizure-related changes in somatostatin in brain tissue and cerebrospinal fluid (CSF) in experimental and human epilepsy. These data strengthen the view that the somatostatinergic system is affected in epilepsy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / metabolism
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Epilepsy / cerebrospinal fluid
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Epilepsy / metabolism*
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Humans
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Models, Biological
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Rats
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Receptors, Neurotransmitter / cerebrospinal fluid
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Receptors, Neurotransmitter / metabolism
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Receptors, Somatostatin
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Somatostatin / cerebrospinal fluid
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Somatostatin / metabolism*
Substances
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Receptors, Neurotransmitter
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Receptors, Somatostatin
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Somatostatin