Strength of T cell receptor signaling strikes again

Leslie J Berg

doi:10.1016/j.immuni.2009.09.008

Strength of T cell receptor signaling strikes again

Immunity. 2009 Oct 16;31(4):529-31. doi: 10.1016/j.immuni.2009.09.008.

Author

Leslie J Berg¹

Affiliation

¹ University of Massachusetts Medical School, Worcester, MA 01655, USA. leslie.berg@umassmed.edu

PMID: 19833081
DOI: 10.1016/j.immuni.2009.09.008

Abstract

In this issue of Immunity, Gomez-Rodriguez et al. (2009) demonstrate that signaling via the Itk kinase, a component of the T cell receptor signaling pathway, is required for interleukin-17A but not interleukin-17F expression in T helper 17 cells.

Publication types

Comment

MeSH terms

Animals
CD4-Positive T-Lymphocytes / immunology*
CD4-Positive T-Lymphocytes / metabolism
CD8-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / metabolism
Humans
Interleukin-17 / immunology
Interleukin-17 / metabolism
NFATC Transcription Factors / immunology
NFATC Transcription Factors / metabolism
Protein-Tyrosine Kinases / genetics
Protein-Tyrosine Kinases / metabolism*
Receptors, Antigen, T-Cell / immunology*
Receptors, Antigen, T-Cell / metabolism
Signal Transduction / immunology
T-Lymphocytes, Helper-Inducer / immunology*
T-Lymphocytes, Helper-Inducer / metabolism

Substances

Interleukin-17
NFATC Transcription Factors
Receptors, Antigen, T-Cell
Protein-Tyrosine Kinases