Abstract
For the nervous system to translate experience into memory and behavior, lasting structural change at synapses must occur. This requirement is clearly evident during critical periods of activity-dependent neural development, and accumulating evidence has established a surprising role for the major histocompatibility complex class I (MHCI) proteins in this process.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / immunology
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Brain / physiology*
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Gene Expression
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Genes, MHC Class I*
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Histocompatibility Antigens Class I / metabolism
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Histocompatibility Antigens Class I / physiology*
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Humans
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Models, Neurological
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Neuronal Plasticity / physiology*
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Neurons / immunology
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Neurons / physiology*
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Receptors, Immunologic / metabolism
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Synapses / physiology*
Substances
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Histocompatibility Antigens Class I
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Receptors, Immunologic