Abstract
The insulin signalling pathway is highly conserved from mammals to Drosophila. Insulin signalling in the fly, as in mammals, regulates a number of physiological functions, including carbohydrate and lipid metabolism, tissue growth and longevity. In the present review, I discuss the molecular mechanisms by which insulin signalling regulates metabolism in Drosophila, comparing and contrasting with the mammalian system. I discuss both the intracellular signalling network, as well as the communication between organs in the fly.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Drosophila / genetics
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Drosophila / metabolism
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Drosophila / physiology*
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism*
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Insulin / metabolism*
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Insulin Receptor Substrate Proteins / metabolism
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Models, Biological
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Phosphatidylinositol 3-Kinases / metabolism
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Phosphorylation
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Receptor, Insulin / genetics
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Receptor, Insulin / metabolism*
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Signal Transduction / physiology*
Substances
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Drosophila Proteins
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Insulin
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Insulin Receptor Substrate Proteins
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Phosphatidylinositol 3-Kinases
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Receptor, Insulin