Abstract
Mycobacterium africanum (MAF) is a common cause of human pulmonary tuberculosis in West Africa. We previously described phenotypic differences between MAF and Mycobacterium tuberculosis (MTB) among 290 patients. In the present analysis, we compared 692 tuberculosis patients infected with the two most common lineages within the (MTB) complex found in the Gambia, namely MAF West African type 2 (39% prevalence) and Euro-American MTB (55% prevalence). We identified additional phenotypic differences between infections with these two organisms. MAF patients were more likely to be older and HIV infected. In addition, they had worse disease on chest X-ray, despite complaining of cough for an equal duration, and were more likely severely malnourished. In this cohort, the prevalence of MAF did not change significantly over a 7-year period.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / epidemiology
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AIDS-Related Opportunistic Infections / microbiology
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AIDS-Related Opportunistic Infections / physiopathology
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Adult
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Americas / epidemiology
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Europe / epidemiology
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Female
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Gambia / epidemiology
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Genotype
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HIV Infections* / complications
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HIV Infections* / epidemiology
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HIV Infections* / virology
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Humans
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Male
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Malnutrition* / complications
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Malnutrition* / epidemiology
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Mycobacterium / classification
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Mycobacterium / genetics
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Mycobacterium / pathogenicity*
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Mycobacterium tuberculosis / classification
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / pathogenicity*
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Phenotype
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Prevalence
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Tuberculosis, Pulmonary* / epidemiology
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Tuberculosis, Pulmonary* / microbiology
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Tuberculosis, Pulmonary* / physiopathology
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Young Adult