Abstract
Cognitive deficits are core features of psychiatric disorders and contribute substantially to functional outcome. It is still unclear, however, how cognitive deficits are related to underlying genetic liability and overt clinical symptoms. Fortunately, animal models of susceptibility genes can illuminate how the products of disease-associated genetic variants affect brain function and ultimately alter behavior. Using as a reference findings from the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia program and the SchizophreniaGene database, we review cognitive data from mutant models of rare and common genetic variants associated with schizophrenia.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alleles
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Animals
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Brain / physiopathology
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Cognition Disorders / genetics*
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Cognition Disorders / physiopathology
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Cognition Disorders / psychology
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Disease Models, Animal*
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Executive Function / physiology
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Genetic Association Studies
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Genetic Markers / genetics
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Genetic Predisposition to Disease / genetics*
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Genetic Predisposition to Disease / psychology
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Humans
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Memory, Short-Term / physiology
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Mice
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Mice, Transgenic
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Nerve Tissue Proteins / genetics
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Schizophrenia / genetics*
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Schizophrenia / physiopathology
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Schizophrenic Psychology*
Substances
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DISC1 protein, human
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Disc1 protein, mouse
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Genetic Markers
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Nerve Tissue Proteins