The many faces of the mitochondrial TIM23 complex

Dejana Mokranjac; Walter Neupert

doi:10.1016/j.bbabio.2010.01.026

The many faces of the mitochondrial TIM23 complex

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1045-54. doi: 10.1016/j.bbabio.2010.01.026. Epub 2010 Jan 28.

Authors

Dejana Mokranjac¹, Walter Neupert

Affiliation

¹ Institute for Physiological Chemistry and Munich Center for Integrated Protein Science CIPSM, Ludwig-Maximilians University, Butenandtstr. 5, 81377 Munich, Germany. dejana.mokranjac@med.uni-muenchen.de

PMID: 20116361
DOI: 10.1016/j.bbabio.2010.01.026

Abstract

The TIM23 complex in the inner membrane of mitochondria mediates import of essentially all matrix proteins and a large number of inner membrane proteins. Here we present an overview on the latest insights into the structure and function of this remarkable molecular machine.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adenosine Triphosphate / metabolism
Animals
Carrier Proteins / chemistry
Carrier Proteins / metabolism
Humans
Mitochondria / metabolism*
Mitochondrial Membrane Transport Proteins / chemistry*
Mitochondrial Membrane Transport Proteins / metabolism*
Mitochondrial Precursor Protein Import Complex Proteins
Models, Biological
Models, Molecular
Multiprotein Complexes / chemistry
Multiprotein Complexes / metabolism
Protein Precursors / chemistry
Protein Precursors / metabolism
Protein Subunits
Protein Transport
Signal Transduction

Substances

Carrier Proteins
Mitochondrial Membrane Transport Proteins
Mitochondrial Precursor Protein Import Complex Proteins
Multiprotein Complexes
Protein Precursors
Protein Subunits
Adenosine Triphosphate