Abstract
The innate immune response is a defense mechanism against infectious agents in both vertebrates and invertebrates, and is in part mediated by the Toll pathway. Toll receptor activation upon exposure to bacteria causes stimulation of Pelle/IRAK kinase, eventually resulting in translocation of the transcription factor NF-kappaB to the nucleus. Here we show that Pellino, a highly conserved protein interacting with activated Pelle/IRAK, acts as a positive regulator of innate immunity in Drosophila.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blotting, Western
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Drosophila / genetics
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Drosophila / immunology*
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Drosophila / metabolism
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Drosophila Proteins / genetics
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Drosophila Proteins / immunology*
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Drosophila Proteins / metabolism
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Immunity, Innate / genetics
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Immunity, Innate / immunology*
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Interleukin-1 Receptor-Associated Kinases / genetics
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Interleukin-1 Receptor-Associated Kinases / immunology
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Interleukin-1 Receptor-Associated Kinases / metabolism
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Nuclear Proteins / genetics
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Nuclear Proteins / immunology*
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Nuclear Proteins / metabolism
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / immunology
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Protein Serine-Threonine Kinases / metabolism
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Reverse Transcriptase Polymerase Chain Reaction
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Signal Transduction / genetics
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Signal Transduction / immunology
Substances
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Drosophila Proteins
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Nuclear Proteins
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pll protein, Drosophila
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Interleukin-1 Receptor-Associated Kinases
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Protein Serine-Threonine Kinases