Binding and interplay of HMG proteins on chromatin: lessons from live cell imaging

Fred Catez; Robert Hock

doi:10.1016/j.bbagrm.2009.11.001

Binding and interplay of HMG proteins on chromatin: lessons from live cell imaging

Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):15-27. doi: 10.1016/j.bbagrm.2009.11.001.

Authors

Fred Catez¹, Robert Hock

Affiliation

¹ Centre de Génétique Moléculaire et Cellulaire, CNRS UMR5534, 16 rue Dubois. F-69622 Villeurbanne, Université de Lyon, Lyon F-69003, France. frederic.catez@cgmc.univ-lyon.fr

PMID: 20123065
DOI: 10.1016/j.bbagrm.2009.11.001

Abstract

Members of the superfamily of high mobility group (HMG) proteins are considered as architectural elements of chromatin. It is now clear that they belong to a network of dynamic chromatin proteins that constantly move around the chromatin fiber thereby dynamically modulating DNA-dependent processes. In this review we discuss how HMGs fused to fluorescent proteins and live cell imaging advanced our understanding in HMG dynamics and function. By presenting the regulation of the dynamic properties of each HMG family in comparison to one another we wish to highlight common themes among the three families, as well as stimulate new ideas from one HMG family in relation to the others and more generally in the dynamic world of chromatin.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Survival
Chromatin / metabolism*
High Mobility Group Proteins / metabolism*
Humans
Imaging, Three-Dimensional*
Protein Binding
Protein Processing, Post-Translational

Substances

Chromatin
High Mobility Group Proteins