Abstract
Cholesterol-derived hormones, the dafachronic acids, play a major role in controlling the life cycle and initiating dauer larva formation of the nematode Caenorhabditis elegans. This Perspective describes recent progress in the synthesis of these steroid hormones and their biological function.
MeSH terms
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Animals
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Caenorhabditis elegans / physiology*
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Caenorhabditis elegans Proteins / biosynthesis
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Caenorhabditis elegans Proteins / physiology*
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Cholesterol / pharmacology
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Gene Expression Regulation, Developmental / drug effects
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Gene Expression Regulation, Developmental / physiology
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Genes, Helminth
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Hormones / pharmacology*
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Larva / drug effects
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Larva / physiology
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Life Cycle Stages / drug effects*
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Life Cycle Stages / physiology
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Longevity / drug effects
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Signal Transduction / physiology
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Stereoisomerism
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Steroids / pharmacology*
Substances
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Caenorhabditis elegans Proteins
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Hormones
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Steroids
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Cholesterol