How the sequence of a gene can tune its translation

Cell. 2010 Apr 16;141(2):227-9. doi: 10.1016/j.cell.2010.03.033.

Abstract

Sixty-one codons specify 20 amino acids, offering cells many options for encoding a polypeptide sequence. Two new studies (Cannarrozzi et al., 2010; Tuller et al., 2010) now foster the idea that patterns of codon usage can control ribosome speed, fine-tuning translation to increase the efficiency of protein synthesis.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Base Sequence
  • Codon*
  • Protein Biosynthesis*
  • Ribosomes / physiology*

Substances

  • Codon