Abstract
New technologies such as high-throughput methods and 13C-isotopologue-profiling analysis are beginning to provide us with insight into the in vivo metabolism of microorganisms, especially in the host cell compartments that are colonized by intracellular bacterial pathogens. In this Review, we discuss the recent progress made in determining the major carbon sources and metabolic pathways used by model intracellular bacterial pathogens that replicate either in the cytosol or in vacuoles of infected host cells. Furthermore, we highlight the possible links between intracellular carbon metabolism and the expression of virulence genes.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Bacteria / metabolism*
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Bacteria / pathogenicity
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Carbon / metabolism*
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Cytosol / microbiology
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Genomic Islands
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Host-Pathogen Interactions
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Listeria monocytogenes / genetics
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Listeria monocytogenes / metabolism
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Listeria monocytogenes / pathogenicity
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / metabolism
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Mycobacterium tuberculosis / pathogenicity
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Peptide Termination Factors / genetics
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Peptide Termination Factors / metabolism
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Salmonella typhi / metabolism
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Salmonella typhi / pathogenicity
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Shigella flexneri / genetics
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Shigella flexneri / metabolism
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Shigella flexneri / pathogenicity
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Vacuoles / microbiology
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Virulence
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Virulence Factors / genetics
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Virulence Factors / metabolism
Substances
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Bacterial Proteins
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Peptide Termination Factors
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PrfA protein, Listeria monocytogenes
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Virulence Factors
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Carbon