Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Biochem Biophys Res Commun. 2010 Jul 9;397(4):756-61. doi: 10.1016/j.bbrc.2010.06.029. Epub 2010 Jun 10.

Abstract

Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8alpha(+) conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8(+) T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3(+) DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8(+) T cells through XCR1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD8 Antigens / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Cell Line
  • Chemokines, C / biosynthesis*
  • Dendritic Cells / immunology*
  • Humans
  • Killer Cells, Natural / immunology
  • Ligands
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C57BL
  • Receptors, Chemokine / biosynthesis*
  • Receptors, G-Protein-Coupled / biosynthesis*

Substances

  • CD8 Antigens
  • Chemokines, C
  • Ligands
  • Receptors, Chemokine
  • Receptors, G-Protein-Coupled
  • XC chemokine receptor 1, mouse
  • XCL1 protein, human
  • XCR1 protein, human
  • Xcl1 protein, mouse