Innate inflammatory response to the malarial pigment hemozoin

Marina T Shio; Fikregabrail A Kassa; Marie-Josée Bellemare; Martin Olivier

doi:10.1016/j.micinf.2010.07.001

Innate inflammatory response to the malarial pigment hemozoin

Microbes Infect. 2010 Nov;12(12-13):889-99. doi: 10.1016/j.micinf.2010.07.001. Epub 2010 Jul 15.

Authors

Marina T Shio¹, Fikregabrail A Kassa, Marie-Josée Bellemare, Martin Olivier

Affiliation

¹ Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada.

PMID: 20637890
DOI: 10.1016/j.micinf.2010.07.001

Abstract

Malaria is an infectious disease caused by parasites of the genus Plasmodium. This intraerythrocytic protozoan produces hemozoin (HZ), an insoluble crystalline metabolite resulting from the heme detoxification mechanism. This review will focus on HZ biosynthesis and synthetic preparation, but in particular on its effect on host's innate inflammatory responses.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Hemeproteins / biosynthesis
Hemeproteins / chemical synthesis
Hemeproteins / immunology*
Humans
Immunity, Innate*
Inflammation / immunology*
Plasmodium / immunology*

Substances

Hemeproteins
hemozoin

Grants and funding

Canadian Institutes of Health Research/Canada