Abstract
Methionine sulfoxide reductase A (msrA) was previously found to increase resistance to oxidative stress and longevity in animals. We identified Drosophila msrA (dmsrA), a Drosophila homolog of human msrA, as a downstream effector of forkhead box O (FOXO) signaling in Drosophila, which enhances resistance to oxidative stress and increases survival under stressed conditions. Additionally, overexpression of dmsrA in neurons extended the lifespan of flies. Moreover, overexpression of dmsrA in fat body cells caused FOXO to translocate to the nucleus, implying that this possible positive feedback loop between dmsrA and FOXO could potentiate the antioxidant activity of dmsrA and increase the lifespan in Drosophila.
Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Active Transport, Cell Nucleus
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Animals
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Animals, Genetically Modified
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Antioxidants / metabolism
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Base Sequence
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DNA Primers / genetics
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism*
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Drosophila melanogaster / genetics
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Drosophila melanogaster / growth & development
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Drosophila melanogaster / metabolism*
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Fat Body / metabolism
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Feedback, Physiological
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Forkhead Transcription Factors / metabolism*
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Gene Expression
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Humans
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JNK Mitogen-Activated Protein Kinases / metabolism
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Longevity / genetics
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Longevity / physiology
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Methionine Sulfoxide Reductases / genetics
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Methionine Sulfoxide Reductases / metabolism*
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Oxidative Stress
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Signal Transduction
Substances
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Antioxidants
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DNA Primers
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Drosophila Proteins
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FOXO protein, Drosophila
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Forkhead Transcription Factors
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Methionine Sulfoxide Reductases
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methionine sulfoxide reductase
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JNK Mitogen-Activated Protein Kinases