Abstract
Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Binding Sites
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Cell Adhesion Molecules / antagonists & inhibitors*
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Cell Adhesion Molecules / metabolism
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HIV Infections / transmission
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Humans
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Lectins, C-Type / antagonists & inhibitors*
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Lectins, C-Type / metabolism
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Receptors, Cell Surface / antagonists & inhibitors*
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Receptors, Cell Surface / metabolism
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Shikimic Acid / chemistry
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Small Molecule Libraries / chemistry*
Substances
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Cell Adhesion Molecules
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DC-specific ICAM-3 grabbing nonintegrin
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Lectins, C-Type
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Receptors, Cell Surface
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Small Molecule Libraries
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Shikimic Acid