CST meets shelterin to keep telomeres in check

Mol Cell. 2010 Sep 10;39(5):665-76. doi: 10.1016/j.molcel.2010.08.024.

Abstract

Telomere protection in budding yeast requires the heterotrimer named CST (for Cdc13-Stn1-Ten1). Recent data show that CST components are conserved and required for telomere stability in a wide range of eukaryotes, even those utilizing the shelterin complex to protect their telomeres. A common function of these proteins might be to stimulate priming at the C-strand gap that remains after telomerase elongation, replication termination, and terminal processing. In light of the budding yeast situation, another conserved function of CST might well be the regulation of telomerase. The cohabitation at telomeres of CST and shelterin components highlights the complexity of telomere biology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cyclin B / genetics
  • Cyclin B / metabolism*
  • DNA Replication / physiology*
  • DNA, Fungal / genetics
  • DNA, Fungal / metabolism*
  • Multiprotein Complexes / genetics
  • Multiprotein Complexes / metabolism
  • Saccharomycetales / genetics
  • Saccharomycetales / metabolism*
  • Schizosaccharomyces pombe Proteins / genetics
  • Schizosaccharomyces pombe Proteins / metabolism*
  • Telomerase / genetics
  • Telomerase / metabolism
  • Telomere / genetics
  • Telomere / metabolism*
  • Telomere-Binding Proteins / genetics
  • Telomere-Binding Proteins / metabolism*

Substances

  • Cdc13 protein, S pombe
  • Cyclin B
  • DNA, Fungal
  • Multiprotein Complexes
  • Schizosaccharomyces pombe Proteins
  • Stn1 protein, S pombe
  • Telomere-Binding Proteins
  • Ten1 protein, S pombe
  • Telomerase