Abstract
G protein-coupled receptors (GPCRs) are versatile signaling molecules that mediate the majority of physiological responses to hormones and neurotransmitters. Recent high-resolution structural insights into GPCR structure and dynamics are beginning to shed light on the molecular basis of this versatility. We use energy landscapes to conceptualize the link between structure and function.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Humans
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Protein Conformation
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Receptors, Adrenergic, beta-2 / chemistry
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Receptors, Adrenergic, beta-2 / physiology
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Receptors, G-Protein-Coupled / chemistry*
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Receptors, G-Protein-Coupled / physiology*
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Rhodopsin / chemistry
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Rhodopsin / physiology
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Thermodynamics*
Substances
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Receptors, Adrenergic, beta-2
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Receptors, G-Protein-Coupled
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Rhodopsin