Abstract
Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / pharmacology*
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Cell Line
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Genes, Immediate-Early
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Herpesvirus 4, Human* / drug effects
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Herpesvirus 4, Human* / genetics
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Herpesvirus 4, Human* / physiology
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Humans
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Resveratrol
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Stilbenes / pharmacology*
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Transcription, Genetic / drug effects
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Viral Proteins / biosynthesis
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Viral Proteins / genetics
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Virion / drug effects
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Virion / metabolism
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Virus Replication / drug effects*
Substances
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Antioxidants
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Stilbenes
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Viral Proteins
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Resveratrol