Ciliary trafficking: CEP290 guards a gated community

Curr Biol. 2010 Nov 9;20(21):R928-31. doi: 10.1016/j.cub.2010.09.058.

Abstract

A recent study reveals that the large coiled-coil protein CEP290 is an integral component of the transition zone between the cell body and the cilium and functions as a gatekeeper to regulate trafficking of ciliary proteins.

MeSH terms

  • Chlamydomonas / genetics
  • Chlamydomonas / metabolism*
  • Chlamydomonas / ultrastructure
  • Cilia / metabolism*
  • Cilia / ultrastructure
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Membrane Proteins / physiology*
  • Plant Proteins / genetics
  • Plant Proteins / metabolism
  • Plant Proteins / physiology*
  • Protein Transport / genetics*

Substances

  • Membrane Proteins
  • Plant Proteins