Statistical genetic issues for genome-wide association studies

Genome. 2010 Nov;53(11):869-75. doi: 10.1139/G10-062.

Abstract

Genotyping technology now allows the rapid and affordable generation of million-SNP profiles for humans, leading to considerable activity in association mapping. Similar activity is anticipated for many plant species, including Brassica. These plant association mapping activities will require the same care in quality control and quality assurance as for humans. The subsequent analyses may draw upon the same body of theory that is described here in the language of quantitative genetics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Data Interpretation, Statistical
  • Gene Frequency
  • Genome, Plant*
  • Genome-Wide Association Study / statistics & numerical data*
  • Genotype
  • Linkage Disequilibrium
  • Phenotype
  • Polymorphism, Single Nucleotide