Pain and the brain: specificity and plasticity of the brain in clinical chronic pain

Vania A Apkarian; Javeria A Hashmi; Marwan N Baliki

doi:10.1016/j.pain.2010.11.010

Pain and the brain: specificity and plasticity of the brain in clinical chronic pain

Pain. 2011 Mar;152(3 Suppl):S49-S64. doi: 10.1016/j.pain.2010.11.010. Epub 2010 Dec 13.

Authors

Vania A Apkarian¹, Javeria A Hashmi, Marwan N Baliki

Affiliation

¹ Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA Departments of Anesthesia and Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

Abstract

We review recent advances in brain imaging in humans, concentrating on advances in our understanding of the human brain in clinical chronic pain. Understanding regarding anatomical and functional reorganization of the brain in chronic pain is emphasized. We conclude by proposing a brain model for the transition of the human from acute to chronic pain.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain / physiopathology*
Humans
Models, Neurological*
Nerve Net / physiopathology*
Neural Inhibition*
Neuronal Plasticity*

Abstract

Publication types

MeSH terms

Grants and funding