Identification of blood microRNAs associated to Parkinsonĭs disease

Regina Margis; Rogério Margis; Carlos R M Rieder

doi:10.1016/j.jbiotec.2011.01.023

Identification of blood microRNAs associated to Parkinsonĭs disease

J Biotechnol. 2011 Mar 20;152(3):96-101. doi: 10.1016/j.jbiotec.2011.01.023. Epub 2011 Feb 3.

Authors

Regina Margis¹, Rogério Margis, Carlos R M Rieder

Affiliation

¹ Neurology Section, Movement Disorders Unit, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035-00 Porto Alegre, RS, Brazil.

PMID: 21295623
DOI: 10.1016/j.jbiotec.2011.01.023

Abstract

The present study demonstrates that blood samples can be used as a source of miRNA identification associated to Parkinson's disease (PD). A set of six differentially expressed microRNAs were identified. They form two groups according to their expression profile in control, non-treated, early-onset and treated Parkinson's disease subjects. While miR-1, miR-22* and miR-29 expression levels allowed to distinguish non-treated PD from healthy subjects, miR-16-2*, miR-26a2* and miR30a differentiated treated from untreated patients. This study is innovative in contributing to the development of effective PD biomarkers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Female
Gene Expression Profiling
Gene Expression Regulation
Humans
Male
MicroRNAs / blood*
MicroRNAs / genetics*
Middle Aged
Parkinson Disease / blood*
Parkinson Disease / genetics*

Substances

MicroRNAs