Universal control mechanism regulating onset of M-phase

Nature. 1990 Apr 5;344(6266):503-8. doi: 10.1038/344503a0.

Abstract

The onset of M-phase is regulated by a mechanism common to all eukaryotic cells. Entry into M-phase is determined by activation of the p34cdc2 protein kinase which requires p34cdc2 dephosphorylation and association with cyclin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CDC2 Protein Kinase
  • Cyclins
  • Enzyme Activation / physiology
  • Genes, Fungal / physiology
  • Genes, Regulator / physiology
  • Invertebrate Hormones / physiology
  • Mitosis / genetics
  • Mitosis / physiology*
  • Oocytes / cytology
  • Phosphoproteins / metabolism*
  • Protein Kinases / genetics
  • Protein Kinases / metabolism*

Substances

  • Cyclins
  • Invertebrate Hormones
  • Phosphoproteins
  • Protein Kinases
  • CDC2 Protein Kinase