piRNAs meet mitochondria

Alexei A Aravin; David C Chan

doi:10.1016/j.devcel.2011.03.003

piRNAs meet mitochondria

Dev Cell. 2011 Mar 15;20(3):287-8. doi: 10.1016/j.devcel.2011.03.003.

Authors

Alexei A Aravin¹, David C Chan

Affiliation

¹ California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. aaa@caltech.edu

PMID: 21397839
DOI: 10.1016/j.devcel.2011.03.003

Abstract

zuc/MitoPLD encodes a conserved enzyme that localizes to mitochondria and hydrolyzes the mitochondria-specific lipid cardiolipin. Surprisingly, zuc/MitoPLD activity is required for Piwi-interacting RNA (piRNA)-mediated silencing of transposable elements in fly and mouse germlines, suggesting that signaling from mitochondria influences the piRNA pathway.

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