An appropriately developed and functional reproductive tract is essential for the natural production of offspring. However, abnormal development or disease, either within or external to the reproductive tract, can cause considerable morbidity and mortality. This Review describes the normal function of each section of the female reproductive tract. Some of the major conditions and diseases that cause reproductive tract dysfunction in women of reproductive age are reviewed, with a focus on endocrine-related dysfunction. As the female reproductive tract is vital for the continuation of the human species, it is crucial to have an improved understanding of how the cells and tissues of this system interact under normal conditions and to define how hormonal and genetic abnormalities cause pathophysiologic derangement of reproduction.