Abstract
Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single β cell, pancreatic islet, whole pancreas, and the intact organism. Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of insulin secretion. This review focuses on our current understanding of the dynamics of insulin secretion in vitro and in vivo and discusses their clinical relevance.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Circadian Rhythm / physiology
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Cyclic AMP / physiology
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Cytoplasmic Granules / metabolism
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Diabetes Mellitus / drug therapy
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Diabetes Mellitus / physiopathology*
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Eating / physiology
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Glucose Metabolism Disorders / physiopathology
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Guanine Nucleotide Exchange Factors / agonists
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Guanine Nucleotide Exchange Factors / physiology
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Humans
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Hypoglycemic Agents / pharmacology
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Hypoglycemic Agents / therapeutic use
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Incretins / physiology
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Insulin / metabolism*
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Insulin Resistance / physiology
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Insulin Secretion
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Islets of Langerhans / metabolism*
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Models, Biological
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Obesity / drug therapy
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Obesity / physiopathology*
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Potassium Channels / drug effects
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Potassium Channels / physiology
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Secretory Rate
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Signal Transduction / drug effects
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Signal Transduction / physiology
Substances
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Guanine Nucleotide Exchange Factors
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Hypoglycemic Agents
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Incretins
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Insulin
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Potassium Channels
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RAPGEF4 protein, human
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Cyclic AMP