Abstract
We found that glia secrete myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Genetically Modified
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Drosophila
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism
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Gene Expression Regulation, Developmental / genetics
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Gene Expression Regulation, Developmental / physiology*
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Green Fluorescent Proteins / genetics
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MicroRNAs / genetics
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MicroRNAs / metabolism
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Models, Neurological*
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Mushroom Bodies / cytology*
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Mushroom Bodies / growth & development
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Mutation / genetics
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Neurogenesis / genetics
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Neuroglia / physiology*
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RNA, Double-Stranded / metabolism
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Signal Transduction / genetics
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Signal Transduction / physiology*
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Transforming Growth Factor beta / genetics
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Transforming Growth Factor beta / metabolism*
Substances
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Drosophila Proteins
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MicroRNAs
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RNA, Double-Stranded
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Transforming Growth Factor beta
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myo protein, Drosophila
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Green Fluorescent Proteins