Drugs: a tangled web of targets

Nature. 2011 Jul 13;475(7355):S9-11. doi: 10.1038/475S9a.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine / adverse effects
  • Alanine / analogs & derivatives
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / physiopathology
  • Amyloid Precursor Protein Secretases / antagonists & inhibitors
  • Amyloid Precursor Protein Secretases / metabolism
  • Amyloid beta-Peptides / antagonists & inhibitors
  • Amyloid beta-Peptides / genetics
  • Amyloid beta-Peptides / immunology
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Antibodies, Monoclonal / immunology
  • Antibodies, Monoclonal / pharmacology
  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Monoclonal, Humanized
  • Azepines / adverse effects
  • Clinical Trials as Topic
  • Disease Progression
  • Genetic Therapy
  • Glycogen Synthase Kinase 3 / antagonists & inhibitors
  • Glycogen Synthase Kinase 3 / metabolism
  • Humans
  • Indoles / pharmacology
  • Indoles / therapeutic use
  • Memantine / pharmacology
  • Memantine / therapeutic use
  • Methylene Blue / therapeutic use
  • Molecular Targeted Therapy* / statistics & numerical data
  • Molecular Targeted Therapy* / trends
  • Nerve Growth Factor / genetics
  • Nerve Growth Factor / therapeutic use
  • Neurofibrillary Tangles / drug effects
  • Phosphorylation
  • tau Proteins / chemistry
  • tau Proteins / metabolism

Substances

  • Amyloid beta-Peptides
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Azepines
  • Indoles
  • N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide
  • tau Proteins
  • Nerve Growth Factor
  • Glycogen Synthase Kinase 3
  • Amyloid Precursor Protein Secretases
  • bapineuzumab
  • latrepirdine
  • Alanine
  • Methylene Blue
  • Memantine