Abstract
N-linked glycosylation, a protein modification system present in all domains of life, is characterized by a high structural diversity of N-linked glycans found among different species and by a large number of proteins that are glycosylated. Based on structural, functional, and phylogenetic approaches, this review discusses the highly conserved processes that are at the basis of this unique general protein modification system.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Archaea / metabolism
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Asparagine / metabolism*
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Bacteria / metabolism
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Cell Membrane / metabolism
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Consensus Sequence
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Cytosol / metabolism
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Endoplasmic Reticulum / metabolism
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Enzyme Activation
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Glycosylation*
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Hexosyltransferases / metabolism
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Membrane Proteins / metabolism
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Phylogeny
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Polysaccharides / metabolism*
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Protein Processing, Post-Translational*
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Substrate Specificity
Substances
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Membrane Proteins
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Polysaccharides
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Asparagine
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Hexosyltransferases
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dolichyl-diphosphooligosaccharide - protein glycotransferase