Abstract
Host antimicrobial mechanisms reduce iron availability to pathogens. Iron proteins influencing the innate immune response include hepcidin, lactoferrin, siderocalin, haptoglobin, hemopexin, Nramp1, ferroportin and the transferrin receptor. Numerous global health threats are influenced by iron status and provide examples of our growing understanding of the connections between infection and iron metabolism.
Copyright © 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Antimicrobial Cationic Peptides / metabolism
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Carrier Proteins / metabolism
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Cation Transport Proteins / metabolism
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HIV / immunology
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HIV / metabolism
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HIV / pathogenicity
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HIV Infections / immunology*
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HIV Infections / virology
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Hepcidins
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Humans
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Immunity, Innate*
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Iron / metabolism*
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Lactoferrin / metabolism
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Lipocalin-2
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Malaria / immunology
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Malaria / metabolism
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Malaria / parasitology
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Mycobacterium tuberculosis / immunology
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Mycobacterium tuberculosis / metabolism
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Mycobacterium tuberculosis / pathogenicity
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Plasmodium / immunology
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Plasmodium / pathogenicity
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Tuberculosis / immunology*
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Tuberculosis / microbiology
Substances
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Antimicrobial Cationic Peptides
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Carrier Proteins
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Cation Transport Proteins
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HAMP protein, human
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Hepcidins
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LCN2 protein, human
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Lipocalin-2
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metal transporting protein 1
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natural resistance-associated macrophage protein 1
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Iron
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Lactoferrin