Abstract
Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease. Better understanding of the cellular pathophysiological processes underlying kidney injury and repair will hopefully result in the design of more targeted therapies to prevent the injury, hasten repair, and minimize chronic progressive kidney disease.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Acute Kidney Injury / immunology
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Acute Kidney Injury / pathology
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Acute Kidney Injury / physiopathology*
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Acute Kidney Injury / prevention & control
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Animals
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Endothelium, Vascular / pathology
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Endothelium, Vascular / physiopathology
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Humans
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Inflammation / immunology
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Inflammation / pathology
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Inflammation / physiopathology
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Ischemia / pathology
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Ischemia / physiopathology*
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Ischemic Preconditioning
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Kidney / blood supply*
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Kidney / pathology
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Mice
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Multiple Organ Failure / physiopathology
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Muscle, Smooth, Vascular / pathology
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Muscle, Smooth, Vascular / physiopathology
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Renal Circulation / physiology
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Sepsis / physiopathology