Abstract
Synthetic biology aims to create functional devices, systems and organisms with novel and useful functions on the basis of catalogued and standardized biological building blocks. Although they were initially constructed to elucidate the dynamics of simple processes, designed devices now contribute to the understanding of disease mechanisms, provide novel diagnostic tools, enable economic production of therapeutics and allow the design of novel strategies for the treatment of cancer, immune diseases and metabolic disorders, such as diabetes and gout, as well as a range of infectious diseases. In this Review, we cover the impact and potential of synthetic biology for biomedical applications.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Aptamers, Nucleotide / therapeutic use
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Biomimetic Materials / therapeutic use
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Biomimetics / methods*
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Biomimetics / trends
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Biotechnology / methods*
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Biotechnology / trends
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Cell Line
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Cell Line, Tumor
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Drug Design
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Epigenomics / methods
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Gene Regulatory Networks
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Genes, Synthetic
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Genetic Engineering / methods*
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Genetic Engineering / trends
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Humans
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Light Signal Transduction
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Mice
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Models, Biological*
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Preventive Medicine / methods
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Preventive Medicine / trends
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Proteomics / methods
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Synthetic Biology* / methods
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Synthetic Biology* / trends
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Systems Integration
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Transcription, Genetic
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Vaccines, Synthetic / therapeutic use
Substances
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Aptamers, Nucleotide
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Vaccines, Synthetic