Cilia and Hedgehog: when and how was their marriage solemnized?

Sudipto Roy

doi:10.1016/j.diff.2011.11.010

Cilia and Hedgehog: when and how was their marriage solemnized?

Differentiation. 2012 Feb;83(2):S43-8. doi: 10.1016/j.diff.2011.11.010. Epub 2011 Dec 6.

Author

Sudipto Roy¹

Affiliation

¹ Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673, Singapore. sudipto@imcb.a-star.edu.sg

PMID: 22154138
DOI: 10.1016/j.diff.2011.11.010

Abstract

Primary cilia are essential for Hedgehog (Hh) signaling in mammals, and this requirement appears to be conserved in other vertebrates as well. Here, I review recent work that has scrutinized the evolution of the link between the Hh pathway and cilia, discuss what we have learnt from these studies and speculate on how this fascinating problem can be further explored.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cilia / metabolism*
Hedgehog Proteins / metabolism*
Humans
Models, Biological
Signal Transduction

Substances

Hedgehog Proteins