The tuberculosis drug streptomycin as a potential cancer therapeutic: inhibition of miR-21 function by directly targeting its precursor

Angew Chem Int Ed Engl. 2012 Jan 23;51(4):1019-23. doi: 10.1002/anie.201106455. Epub 2011 Dec 15.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / chemistry
  • Antitubercular Agents / pharmacology*
  • Apoptosis / drug effects*
  • Apoptosis Regulatory Proteins / genetics
  • Apoptosis Regulatory Proteins / metabolism
  • Cell Line, Tumor
  • Humans
  • MicroRNAs / antagonists & inhibitors*
  • MicroRNAs / metabolism
  • Neoplasms / drug therapy
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Streptomycin / chemistry
  • Streptomycin / pharmacology*
  • Ultraviolet Rays

Substances

  • Antitubercular Agents
  • Apoptosis Regulatory Proteins
  • MIRN21 microRNA, human
  • MicroRNAs
  • PDCD4 protein, human
  • RNA-Binding Proteins
  • Streptomycin