Abstract
Immunodeficient mice bearing an IL2rγ(null) mutation permit engraftment of a functional human immune system and study of human-specific infectious agents that was not previously possible.
© 2011 New York Academy of Sciences.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Communicable Diseases / etiology*
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Disease Models, Animal
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HLA Antigens / genetics
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Humans
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Interleukin Receptor Common gamma Subunit / deficiency
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Interleukin Receptor Common gamma Subunit / genetics
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Mice
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Mice, Inbred NOD
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Mice, SCID
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Mice, Transgenic
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Models, Immunological
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Neoplasms / therapy
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Receptors, Immunologic / genetics
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Receptors, Immunologic / immunology
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Regenerative Medicine
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T-Lymphocytes / immunology
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Transplantation Chimera / immunology
Substances
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HLA Antigens
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Il2rg protein, mouse
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Interleukin Receptor Common gamma Subunit
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Ptpns1 protein, mouse
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Receptors, Immunologic