Discovery and development of spleen tyrosine kinase (SYK) inhibitors

J Med Chem. 2012 Apr 26;55(8):3614-43. doi: 10.1021/jm201271b. Epub 2012 Feb 14.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Drug Discovery
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Humans
  • Hypersensitivity / immunology
  • Intracellular Signaling Peptides and Proteins / antagonists & inhibitors*
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Mice
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Protein-Tyrosine Kinases / genetics
  • Protein-Tyrosine Kinases / metabolism
  • Structure-Activity Relationship
  • Syk Kinase
  • ZAP-70 Protein-Tyrosine Kinase / antagonists & inhibitors
  • ZAP-70 Protein-Tyrosine Kinase / metabolism

Substances

  • Enzyme Inhibitors
  • Intracellular Signaling Peptides and Proteins
  • Protein-Tyrosine Kinases
  • SYK protein, human
  • Syk Kinase
  • Syk protein, mouse
  • ZAP-70 Protein-Tyrosine Kinase