Abstract
TFII-I transcription factors play an essential role during early vertebrate embryogenesis. Genome-wide mapping studies by ChIP-seq and ChIP-chip revealed that TFII-I primes multiple genomic loci in mouse embryonic stem cells and embryonic tissues. Moreover, many TFII-I-bound regions co-localize with H3K4me3/K27me3 bivalent chromatin within the promoters of lineage-specific genes. This minireview provides a summary of current knowledge regarding the function of TFII-I in epigenetic control of stem cell differentiation.
Copyright © 2012 Wiley Periodicals, Inc.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Differentiation*
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Chromatin / genetics
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Chromatin / metabolism
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Embryo, Mammalian / cytology
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Embryo, Mammalian / embryology
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Embryo, Mammalian / metabolism
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Embryonic Development
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Embryonic Stem Cells / cytology*
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Embryonic Stem Cells / metabolism
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Epigenesis, Genetic*
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Gene Expression Regulation, Developmental*
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Histones / genetics
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Histones / metabolism
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Mice
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Promoter Regions, Genetic
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Signal Transduction
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Transcription Factors, TFII / genetics
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Transcription Factors, TFII / metabolism*
Substances
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Chromatin
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Gtf2i protein, mouse
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Histones
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Transcription Factors, TFII