Getting RNA and protein in phase

Stephanie C Weber; Clifford P Brangwynne

doi:10.1016/j.cell.2012.05.022

Getting RNA and protein in phase

Cell. 2012 Jun 8;149(6):1188-91. doi: 10.1016/j.cell.2012.05.022.

Authors

Stephanie C Weber¹, Clifford P Brangwynne

Affiliation

¹ Princeton University, Department of Chemical and Biological Engineering, NJ 08544, USA.

PMID: 22682242
DOI: 10.1016/j.cell.2012.05.022

Abstract

Nonmembrane-bound organelles such as RNA granules behave like dynamic droplets, but the molecular details of their assembly are poorly understood. Several recent papers identify structural features that drive granule assembly, shedding light on how phase transitions functionally organize the cell and may lead to pathological protein aggregation.

Publication types

Review

MeSH terms

Animals
Cell Nucleus / metabolism
Cell Physiological Phenomena
Cytoplasm / metabolism
Humans
Proteins / chemistry*
Proteins / metabolism
RNA / chemistry*
RNA / metabolism
Ribonucleoproteins / chemistry*

Substances

Proteins
Ribonucleoproteins
RNA

Grants and funding

DP2 GM105437/GM/NIGMS NIH HHS/United States