Selective role of Mediator tail module in the transcription of highly regulated genes in yeast

Suraiya A Ansari; Randall H Morse

doi:10.4161/trns.19840

Selective role of Mediator tail module in the transcription of highly regulated genes in yeast

Transcription. 2012 May-Jun;3(3):110-4. doi: 10.4161/trns.19840.

Authors

Suraiya A Ansari¹, Randall H Morse

Affiliation

¹ Laboratory of Molecular Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, USA. sansari@wadsworth.org

Abstract

The tail module subunits of Mediator complex are targets of activators both in yeast and metazoans. Here we discuss recent evidence from studies in yeast for tail module specificity for SAGA-dependent, TATA-containing genes including highly regulated stress response genes, and for independent recruitment and function of the tail module.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Gene Expression Regulation, Fungal*
Genes, Regulator*
Mediator Complex / genetics*
Mediator Complex / metabolism
Promoter Regions, Genetic
Protein Subunits / genetics
Protein Subunits / metabolism
Saccharomyces cerevisiae / genetics*
Saccharomyces cerevisiae / metabolism
Saccharomyces cerevisiae Proteins / genetics*
Saccharomyces cerevisiae Proteins / metabolism
Selection, Genetic
Stress, Physiological
Transcription, Genetic

Substances

Mediator Complex
Protein Subunits
Saccharomyces cerevisiae Proteins