Abstract
We found that, during the formation of the mouse barrel cortex, NG2 cells received glutamatergic synapses from thalamocortical fibers and preferentially accumulated along septa separating the barrels. Sensory deprivation reduced thalamocortical inputs on NG2 cells and increased their proliferation, leading to a more uniform distribution in the deprived barrels. Thus, early sensory experience regulates thalamocortical innervation on NG2 cells, as well as their proliferation and distribution during development.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cell Count
-
Cell Proliferation
-
DNA-Binding Proteins
-
Darkness
-
Excitatory Postsynaptic Potentials / physiology
-
Glutamates / physiology
-
Immunohistochemistry
-
Mice
-
Mice, Transgenic
-
Microscopy, Confocal
-
Microscopy, Fluorescence
-
Nerve Fibers / physiology
-
Nerve Tissue Proteins / physiology
-
Neural Stem Cells / physiology*
-
Nuclear Proteins / physiology
-
Oligodendroglia / physiology
-
Patch-Clamp Techniques
-
Somatosensory Cortex / physiology*
-
Thalamus / physiology
-
Vesicular Glutamate Transport Protein 2 / physiology
-
Vibrissae / innervation
-
Vibrissae / physiology
Substances
-
DNA-Binding Proteins
-
Glutamates
-
Nerve Tissue Proteins
-
NeuN protein, mouse
-
Nuclear Proteins
-
Slc17a6 protein, mouse
-
Vesicular Glutamate Transport Protein 2