Abstract
To metastasize, cancer cells must be able to complete cell division in environments very different from their tissue of origin. We suggest that mitotic cell rounding, aided by several actin-regulatory oncogenes, may facilitate this process in a robust, context-independent manner.
Copyright © 2012 WILEY Periodicals, Inc.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actins / metabolism
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Adaptation, Physiological
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Animals
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Cell Division
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Cytoskeletal Proteins / metabolism
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Humans
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Membrane Proteins / metabolism
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Mitosis*
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Neoplasm Metastasis
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Neoplasms / genetics
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Neoplasms / metabolism*
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Neoplasms / pathology*
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Oncogenes
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Proto-Oncogene Proteins / metabolism
Substances
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Actins
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Cytoskeletal Proteins
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ECT2 protein, human
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Membrane Proteins
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Proto-Oncogene Proteins
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ezrin
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radixin