Abstract
Three new members of the angucycline class of antibiotics, pseudonocardones A-C (1-3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1-3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Actinomycetales / chemistry*
-
Animals
-
Anopheles / drug effects
-
Anthraquinones / chemistry
-
Anthraquinones / isolation & purification*
-
Anthraquinones / pharmacology*
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / isolation & purification*
-
Anti-Bacterial Agents / pharmacology*
-
Antimalarials / chemistry
-
Antimalarials / isolation & purification*
-
Antimalarials / pharmacology*
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / isolation & purification*
-
Antineoplastic Agents / pharmacology*
-
Ants / microbiology*
-
Bacillus subtilis / drug effects
-
Caenorhabditis elegans / drug effects
-
Drug Screening Assays, Antitumor
-
Escherichia coli / drug effects
-
Hep G2 Cells
-
Humans
-
Liver / microbiology
-
Microbial Sensitivity Tests
-
Plasmodium berghei / drug effects
-
Saccharomyces cerevisiae / drug effects
-
Sporozoites / drug effects
-
Symbiosis*
Substances
-
Anthraquinones
-
Anti-Bacterial Agents
-
Antimalarials
-
Antineoplastic Agents
-
pseudonocardone A
-
pseudonocardone B
-
pseudonocardone C