Comet: an open-source MS/MS sequence database search tool

Jimmy K Eng; Tahmina A Jahan; Michael R Hoopmann

doi:10.1002/pmic.201200439

Comet: an open-source MS/MS sequence database search tool

Proteomics. 2013 Jan;13(1):22-4. doi: 10.1002/pmic.201200439. Epub 2012 Dec 4.

Authors

Jimmy K Eng¹, Tahmina A Jahan, Michael R Hoopmann

Affiliation

¹ Department of Genome Sciences, University of Washington, Seattle, WA 98195-8050, USA. engj@u.washington.edu

PMID: 23148064
DOI: 10.1002/pmic.201200439

Abstract

Proteomics research routinely involves identifying peptides and proteins via MS/MS sequence database search. Thus the database search engine is an integral tool in many proteomics research groups. Here, we introduce the Comet search engine to the existing landscape of commercial and open-source database search tools. Comet is open source, freely available, and based on one of the original sequence database search tools that has been widely used for many years.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Amino Acid Sequence
Databases, Protein*
Humans
Peptides / genetics*
Proteins / genetics*
Proteomics
Search Engine
Software*
Tandem Mass Spectrometry

Substances

Peptides
Proteins