Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

Paul G Arnison; Mervyn J Bibb; Gabriele Bierbaum; Albert A Bowers; Tim S Bugni; Grzegorz Bulaj; Julio A Camarero; Dominic J Campopiano; Gregory L Challis; Jon Clardy; Paul D Cotter; David J Craik; Michael Dawson; Elke Dittmann; Stefano Donadio; Pieter C Dorrestein; Karl-Dieter Entian; Michael A Fischbach; John S Garavelli; Ulf Göransson; Christian W Gruber; Daniel H Haft; Thomas K Hemscheidt; Christian Hertweck; Colin Hill; Alexander R Horswill; Marcel Jaspars; Wendy L Kelly; Judith P Klinman; Oscar P Kuipers; A James Link; Wen Liu; Mohamed A Marahiel; Douglas A Mitchell; Gert N Moll; Bradley S Moore; Rolf Müller; Satish K Nair; Ingolf F Nes; Gillian E Norris; Baldomero M Olivera; Hiroyasu Onaka; Mark L Patchett; Joern Piel; Martin J T Reaney; Sylvie Rebuffat; R Paul Ross; Hans-Georg Sahl; Eric W Schmidt; Michael E Selsted; Konstantin Severinov; Ben Shen; Kaarina Sivonen; Leif Smith; Torsten Stein; Roderich D Süssmuth; John R Tagg; Gong-Li Tang; Andrew W Truman; John C Vederas; Christopher T Walsh; Jonathan D Walton; Silke C Wenzel; Joanne M Willey; Wilfred A van der Donk

doi:10.1039/c2np20085f

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f.

Authors

Paul G Arnison¹, Mervyn J Bibb, Gabriele Bierbaum, Albert A Bowers, Tim S Bugni, Grzegorz Bulaj, Julio A Camarero, Dominic J Campopiano, Gregory L Challis, Jon Clardy, Paul D Cotter, David J Craik, Michael Dawson, Elke Dittmann, Stefano Donadio, Pieter C Dorrestein, Karl-Dieter Entian, Michael A Fischbach, John S Garavelli, Ulf Göransson, Christian W Gruber, Daniel H Haft, Thomas K Hemscheidt, Christian Hertweck, Colin Hill, Alexander R Horswill, Marcel Jaspars, Wendy L Kelly, Judith P Klinman, Oscar P Kuipers, A James Link, Wen Liu, Mohamed A Marahiel, Douglas A Mitchell, Gert N Moll, Bradley S Moore, Rolf Müller, Satish K Nair, Ingolf F Nes, Gillian E Norris, Baldomero M Olivera, Hiroyasu Onaka, Mark L Patchett, Joern Piel, Martin J T Reaney, Sylvie Rebuffat, R Paul Ross, Hans-Georg Sahl, Eric W Schmidt, Michael E Selsted, Konstantin Severinov, Ben Shen, Kaarina Sivonen, Leif Smith, Torsten Stein, Roderich D Süssmuth, John R Tagg, Gong-Li Tang, Andrew W Truman, John C Vederas, Christopher T Walsh, Jonathan D Walton, Silke C Wenzel, Joanne M Willey, Wilfred A van der Donk

Affiliation

¹ Prairie Plant Systems Inc, Botanical Alternatives Inc, Suite 176, 8B-3110 8th Street E, Saskatoon, SK, S7H 0W2, Canada.

Abstract

This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.

Publication types

Review

MeSH terms

Amino Acid Sequence
Biological Products* / chemical synthesis
Biological Products* / chemistry
Biological Products* / classification
Biological Products* / pharmacology
Humans
Molecular Sequence Data
Molecular Structure
Peptides* / chemical synthesis
Peptides* / chemistry
Peptides* / classification
Peptides* / pharmacology
Protein Processing, Post-Translational
Ribosomes / genetics
Ribosomes / metabolism*

Substances

Biological Products
Peptides

Abstract

Publication types

MeSH terms

Substances

Grants and funding