tRNA modifications: necessary for correct tRNA-derived fragments during the recovery from stress?

Zeljko Durdevic; Matthias Schaefer

doi:10.1002/bies.201200158

tRNA modifications: necessary for correct tRNA-derived fragments during the recovery from stress?

Bioessays. 2013 Apr;35(4):323-7. doi: 10.1002/bies.201200158. Epub 2013 Jan 11.

Authors

Zeljko Durdevic¹, Matthias Schaefer

Affiliation

¹ Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany.

PMID: 23315679
DOI: 10.1002/bies.201200158

Abstract

Endonuclease-mediated tRNA fragmentation has been observed in many species suggesting functional importance for tRNA fragments. The size distribution of tRNA-derived fragments indicates the existence of mechanisms that protect tRNAs and their fragments from total degradation by exonucleases. Could post-transcriptional modifications be important for the controlled processing of tRNAs?

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Nucleic Acid Conformation*
Protein Biosynthesis
RNA Processing, Post-Transcriptional
RNA, Transfer / chemistry*
RNA, Transfer / genetics*
Stress, Physiological / genetics*

Substances

RNA, Transfer