H2A.Z sets the stage in ESCs

Ruchi Pandey; Yali Dou

doi:10.1016/j.stem.2013.01.012

H2A.Z sets the stage in ESCs

Cell Stem Cell. 2013 Feb 7;12(2):143-4. doi: 10.1016/j.stem.2013.01.012.

Authors

Ruchi Pandey¹, Yali Dou

Affiliation

¹ Department of Pathology and Biological Chemistry, University of Michigan, Ann Arbor, MI 48019, USA.

PMID: 23395439
DOI: 10.1016/j.stem.2013.01.012

Abstract

ESCs undergo drastic changes in chromatin states during differentiation. Two recent papers in Cell (Li et al., 2012) and Cell Stem Cell (Hu et al., 2013) demonstrate that histone variant H2A.Z plays essential roles in this process by preconfiguring nucleosomes for depletion and recruiting transcription cofactors to cis-regulatory elements.

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