Endocytosis regulates VEGF signalling during angiogenesis

Nat Cell Biol. 2013 Mar;15(3):233-5. doi: 10.1038/ncb2705.

Abstract

Endocytosis has proved to be a versatile mechanism regulating diverse cellular processes, ranging from nutrient uptake to intracellular signal transduction. New work reinforces the importance of endocytosis for VEGF receptor signalling and angiogenesis in the developing eye, and describes a mechanism for its differential regulation in angiogenic versus quiescent endothelial cells.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Adaptor Proteins, Vesicular Transport / metabolism*
  • Animals
  • Apoptosis Regulatory Proteins
  • Cell Adhesion Molecules / metabolism*
  • Cell Cycle Proteins
  • Endocytosis / physiology*
  • Endothelium, Vascular / cytology*
  • Ephrin-B2 / metabolism*
  • Female
  • Humans
  • Male
  • Neovascularization, Physiologic*
  • Protein Kinase C / metabolism*
  • Receptors, Vascular Endothelial Growth Factor / metabolism*

Substances

  • Adaptor Proteins, Signal Transducing
  • Adaptor Proteins, Vesicular Transport
  • Apoptosis Regulatory Proteins
  • Cell Adhesion Molecules
  • Cell Cycle Proteins
  • Dab2 protein, mouse
  • Ephrin-B2
  • Pard3 protein, mouse
  • Receptors, Vascular Endothelial Growth Factor
  • PKC-3 protein
  • Protein Kinase C