Enclosing chromatin: reassembly of the nucleus after open mitosis

Cornelia Wandke; Ulrike Kutay

doi:10.1016/j.cell.2013.02.046

Enclosing chromatin: reassembly of the nucleus after open mitosis

Cell. 2013 Mar 14;152(6):1222-5. doi: 10.1016/j.cell.2013.02.046.

Authors

Cornelia Wandke¹, Ulrike Kutay

Affiliation

¹ Institute of Biochemistry, Department of Biology, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland.

PMID: 23498932
DOI: 10.1016/j.cell.2013.02.046

Abstract

During mitosis in vertebrate cells, the nuclear envelope undergoes extensive structural reorganization, starting with the retraction of nuclear membranes into the ER at mitotic onset and ending with the re-enclosure of chromatin by ER-derived membranes during mitotic exit. Here, we review our current understanding of postmitotic nuclear assembly.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Nucleus / metabolism*
Endoplasmic Reticulum / metabolism
Humans
Mitosis*
Models, Biological*
Nuclear Envelope / metabolism*