Abstract
In the Drosophila female germline, spatially and temporally specific translation of mRNAs governs both stem cell maintenance and the differentiation of their progeny. However, the mechanisms that control and coordinate different modes of translational repression within this lineage remain incompletely understood. Here we present data showing that Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early cyst development, suggesting that this protein helps to repress the translation of nanos mRNA. Together with recently published studies, these data suggest that Mei-P26 mediates both GSC self-renewal and germline differentiation through distinct modes of translational repression depending on the presence of Bam.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Animals, Genetically Modified
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DNA Helicases / metabolism*
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism*
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Drosophila melanogaster / embryology*
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Drosophila melanogaster / genetics
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Drosophila melanogaster / metabolism*
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Embryonic Stem Cells / cytology
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Embryonic Stem Cells / metabolism
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Female
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Gene Expression Regulation, Developmental
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Ovary / cytology
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Ovary / embryology*
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Ovary / metabolism*
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Ovum / cytology
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Ovum / metabolism
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / metabolism*
Substances
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Drosophila Proteins
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Mei-P26 protein, Drosophila
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RNA, Messenger
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RNA-Binding Proteins
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Sxl protein, Drosophila
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bam protein, Drosophila
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nos protein, Drosophila
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DNA Helicases
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bgcn protein, Drosophila